{"id":585,"date":"2019-09-03T13:11:59","date_gmt":"2019-09-03T05:11:59","guid":{"rendered":"http:\/\/u5.cfoh.org.tw\/?page_id=585"},"modified":"2024-11-25T15:06:27","modified_gmt":"2024-11-25T07:06:27","slug":"ga-ii","status":"publish","type":"page","link":"https:\/\/www.cfoh.org.tw\/index.php\/item\/ga-ii\/","title":{"rendered":"\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b (GA II)"},"content":{"rendered":"\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>\u4ec0\u9ebc\u662f\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b\uff1f<\/strong><\/span><\/p>\n<p style=\"text-align: justify; padding-left: 40px;\">\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b\u662f\u8102\u80aa\u9178\u6c27\u5316\u904e\u7a0b\u7570\u5e38\u7684\u75be\u75c5\uff0c\u8d77\u56e0\u70ba\u4f4d\u65bc\u7c92\u817a\u9ad4\u57fa\u8cea\u5167Electron Transfer Flavoprotein (ETF)\u9175\u7d20\u6216\u4f4d\u65bc\u7c92\u817a\u9ad4\u7684\u5167\u819c\u4e0aETF-ubiquinone oxidoreductase (ETF:QO\uff1bETFDH)\u529f\u80fd\u7570\u5e38\uff0c\u5f71\u97ff\u4eba\u9ad4\u5206\u89e3\u86cb\u767d\u8cea\u548c\u8102\u80aa\u7522\u751f\u80fd\u91cf\u7684\u80fd\u529b\u3002\u60a3\u8005\u6703\u56e0\u70ba\u9ad4\u5167\u7121\u6cd5\u5b8c\u5168\u4ee3\u8b1d\u86cb\u767d\u8cea\u548c\u8102\u80aa\uff0c\u5c0e\u81f4\u8840\u6db2\u548c\u7d44\u7e54\u8b8a\u5f97\u904e\u65bc\u9178\u6027\uff0c\u9032\u800c\u9020\u6210\u4ee3\u8b1d\u6027\u7684\u9178\u4e2d\u6bd2\u3002<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b<\/strong><strong>\u60a3\u8005\u75c7\u72c0<\/strong><\/span><\/p>\n<p style=\"text-align: justify; padding-left: 40px;\">\u75c5\u60a3\u767c\u75c5\u5e74\u9f61\u5dee\u7570\u5f88\u5927\uff0c\u56b4\u91cd\u7a0b\u5ea6\u4ea6\u4e0d\u76e1\u76f8\u540c\uff0c\u76ee\u524d\u6982\u62ec\u53ef\u4ee5\u5206\u4f5c\u4e09\u578b\uff0c\u5206\u5225\u70ba: \u7b2c\u4e00\u578b\u70ba\u65b0\u751f\u5152\u578b\u5408\u4f75\u5148\u5929\u7570\u5e38\uff0c\u7b2c\u4e8c\u578b\u65b0\u751f\u5152\u578b\u7121\u5148\u5929\u7570\u5e38\u53ca\u7b2c\u4e09\u578b\u665a\u767c\u578b\uff0c\u65b0\u751f\u5152\u767c\u75c5\u7684\u60a3\u8005\u901a\u5e38\u8f03\u7121\u6cd5\u5b58\u6d3b\uff0c\u665a\u767c\u578b\u901a\u5e38\u662f\u5e74\u7d00\u7a0d\u9577\u751a\u81f3\u6709\u4e9b\u5230\u4e86\u6210\u4eba\u6642\u624d\u6709\u75c7\u72c0\u3002<\/p>\n<ul>\n<li style=\"text-align: justify;\"><strong>\u7b2c\u4e00\u578b\u65b0\u751f\u5152\u578b\u5408\u4f75\u5148\u5929\u7570\u5e38\uff1a<\/strong>\u60a3\u8005\u901a\u5e38\u5728\u51fa\u751f\u5f8c24\u5c0f\u6642\u5167\u51fa\u73fe\u56b4\u91cd\u7684\u975e\u916e\u75c7\u6027\u4f4e\u8840\u7cd6\uff0c\u5f35\u529b\u6e1b\u9000\uff0c\u809d\u816b\u5927\u548c\u56b4\u91cd\u7684\u4ee3\u8b1d\u6027\u9178\u4e2d\u6bd2\u3002\u5148\u5929\u7570\u5e38\u5305\u62ec\u591a\u56ca\u814e\u3001\u4e2d\u81c9\u767c\u80b2\u4e0d\u5168\u4ee5\u53ca\u8166\u90e8\u6216\u80a2\u9ad4\u7570\u5e38\u3002\u5927\u591a\u6578\u4eba\u5728\u751f\u547d\u7684\u7b2c\u4e00\u5468\u6b7b\u4ea1\u3002<\/li>\n<li style=\"text-align: justify;\"><strong>\u7b2c\u4e8c\u578b\u65b0\u751f\u5152\u578b\u7121\u5148\u5929\u7570\u5e38\uff1a<\/strong>\u60a3\u8005\u901a\u5e38\u5728\u51fa\u751f\u5f8c24-48\u5c0f\u6642\u51fa\u73fe\u4e0b\u4e18\u8166\uff0c\u547c\u5438\u6025\u4fc3\uff0c\u809d\u816b\u5927\uff0c\u4ee3\u8b1d\u6027\u9178\u4e2d\u6bd2\u548c\u4f4e\u9240\u8840\u75c7\uff0c\u8eab\u9ad4\u4ea6\u53ef\u80fd\u6703\u6709\u81ed\u8173\u4e2b\u7684\u5473\u9053\u3002\u5927\u591a\u6578\u4eba\u5728\u751f\u547d\u7684\u7b2c\u4e00\u5468\u6b7b\u4ea1\uff0c\u4f46\u6709\u4e9b\u4eba\u6d3b\u4e86\u5e7e\u500b\u6708\uff0c\u901a\u5e38\u6b7b\u65bc\u56b4\u91cd\u7684\u5fc3\u808c\u75c5\u8b8a\u3002<\/li>\n<li style=\"text-align: justify;\"><strong>\u665a\u767c\u578b<\/strong>\u901a\u5e38\u662f\u5e74\u7d00\u7a0d\u9577(\u5b69\u7ae5\u665a\u671f)\u751a\u81f3\u6709\u4e9b\u5230\u4e86\u6210\u4eba\u6642\u624d\u6709\u75c7\u72c0\uff0c\u901a\u5e38\u7b2c\u4e00\u500b\u81e8\u5e8a\u75c7\u72c0\u70ba\u808c\u8089\u7121\u529b\u3002\u9019\u4e9b\u60a3\u8005\u6703\u6709\u9593\u6b47\u6027\u767c\u4f5c\u5641\u5fc3\u3001\u5614\u5410\u3001\u660f\u7761\u3001\u865b\u5f31\u3001\u7121\u529b\u53ca\u809d\u81df\u816b\u5927\u7b49\u3002\u901a\u5e38\u5728\u67d0\u4e9b\u885d\u64ca\u4e0b(\u5982\u75c5\u6bd2\u611f\u67d3\uff0c\u904b\u52d5)\u6642\uff0c\u6703\u6709\u4e00\u6bb5\u6642\u9593\u767c\u751f\u4f4e\u8840\u7cd6\u3002\u9019\u6a23\u7684\u4f4e\u8840\u7cd6\u72c0\u6cc1\u6709\u53ef\u80fd\u6703\u5f88\u56b4\u91cd\uff0c\u4e5f\u6703\u8b93\u60a3\u8005\u611f\u5230\u975e\u5e38\u865b\u5f31\u3001\u8eab\u5f62\u6416\u6643\u3001\u982d\u6688\u76ee\u7729\u3002<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>\u767c\u751f\u7387\u53ca\u907a\u50b3\u6a21\u5f0f<\/strong><\/span><\/p>\n<p style=\"text-align: justify; padding-left: 40px;\">\u76ee\u524d\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b\u5df2\u5217\u70ba\u6211\u570b\u516c\u544a\u7f55\u898b\u75be\u75c5\uff0c\u53f0\u7063\u5730\u5340\u7684\u767c\u751f\u7387\u7d04\u70ba53\u842c\u5206\u4e4b\u4e00\u3002\u4f4d\u65bc\u7b2c17\u865f\u67d3\u8272\u9ad4\u7684\u77ed\u81c2(17p13\u00a0.1)<\/p>\n<p style=\"text-align: justify; padding-left: 40px;\">\u6b64\u75be\u75c5\u907a\u50b3\u6a21\u5f0f\u70ba\u9ad4\u67d3\u8272\u9ad4\u96b1\u6027\u907a\u50b3\uff0c\u81f4\u75c5\u57fa\u56e0\u5305\u62ec<em>ETFA<\/em>\u57fa\u56e0(15q24.2-q24.3)\u3001<em>ETFB<\/em>\u57fa\u56e0(19q13.41)\u53ca<em>ETFDH<\/em>\u57fa\u56e0(4q32.1)\uff0c\u5206\u5225\u8ca0\u8cacElectron Transfer Flavoprotein\u548cETF-ubiquinone oxidoreductase\u5169\u500b\u9175\u7d20\u7684\u88fd\u9020\u3002\u9019\u5169\u500b\u9175\u7d20\u626e\u6f14\u8457\u5206\u89e3\u8102\u80aa(\u8102\u80aa\u9178\u03b2-\u6c27\u5316)\u3001\u86cb\u767d\u8cea(\u652f\u93c8\u80fa\u57fa\u9178\u3001\u96e2\u80fa\u9178\u4ee5\u53ca\u808c\u80fa\u9178\u70ba\u4e3b)\u4ee5\u53ca\u81bd\u9e7c(choline)\u7684\u91cd\u8981\u89d2\u8272\u3002\u56e0\u6b64\u7f3a\u5931\u6703\u9020\u6210\u8102\u80aa\u9178\u6c27\u5316\u904e\u7a0b\u7570\u5e38\uff0c\u96e2\u6c28\u9178\u548c\u652f\u93c8\u80fa\u57fa\u9178\u4ee3\u8b1d\u904e\u7a0b\u7570\u5e38\uff0c\u5f71\u97ff\u4eba\u9ad4\u5206\u89e3\u8102\u80aa\u7522\u751f\u80fd\u91cf\u7684\u80fd\u529b\uff0c\u4ee5\u53ca\u4ee3\u8b1d\u6027\u7684\u9178\u4e2d\u6bd2\u3002<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>\u65b0\u751f\u5152\u7be9\u6aa2\u7591\u967d\u6027\u4e4b\u8655\u7406<\/strong><\/span><\/p>\n<p style=\"text-align: justify; padding-left: 40px;\">\u65b0\u751f\u5152\u7be9\u6aa2\u65b9\u6cd5\u70ba\u5229\u7528\u4e32\u806f\u8cea\u8b5c\u5100\u6e2c\u91cf\u9ad4\u5167\u8840\u4e2dC4-C16\u91af\u57fa\u8089\u9e7c\u7684\u542b\u91cf\u53ca\u8907\u5408\u91af\u57fa\u8089\u9e7c\u6bd4\u4f8b\u3002\u7576C4-C16\u91af\u57fa\u8089\u9e7c\u7684\u542b\u91cf\u6fc3\u5ea6\u9ad8\u65bc\u6b63\u5e38\u503c\u6216\u8907\u5408\u91af\u57fa\u8089\u9e7c\u6bd4\u4f8b\u7570\u5e38\uff0c\u5c07\u63a5\u7372\u63a1\u96c6\u9662\u6240\u901a\u77e5\uff0c\u8acb\u914d\u5408\u91ab\u7642\u4eba\u54e1\u6307\u793a\u9032\u884c\u8907\u6aa2\u3002\u82e5\u65b0\u751f\u5152\u6709\u76f8\u95dc\u81e8\u5e8a\u75c7\u72c0\u6642\uff0c\u8acb\u7acb\u5373\u8207\u65b0\u751f\u5152\u7be9\u6aa2\u4e2d\u5fc3\u6216\u7576\u5730\u6240\u5c6c\u8f49\u4ecb\u91ab\u9662\u91ab\u5e2b\u806f\u7d61\uff0c\u5c0b\u6c42\u53ca\u6642\u7684\u91ab\u7642\u5354\u52a9\u3002<\/p>\n<p style=\"text-align: justify; padding-left: 40px;\">\u8907\u6aa2\u6642\u5c07\u9032\u4e00\u6b65\u9032\u884c\u57fa\u56e0\u7a81\u8b8a\u6aa2\u6e2c\u4f86\u5354\u52a9\u5224\u5b9a\uff0c\u7576\u57fa\u56e0\u7a81\u8b8a\u6aa2\u6e2c\u767c\u73fe\u8b8a\u7570\u4f4d\u9ede\u6216\u8907\u6aa2\u8840\u7247C4-C16\u91af\u57fa\u8089\u9e7c\u7684\u542b\u91cf\u4f9d\u7136\u7570\u5e38\uff0c\u5c07\u8f49\u4ecb\u81f3\u6307\u5b9a\u78ba\u8a3a\u91ab\u9662\u9032\u884c\u78ba\u8a3a\u8a55\u4f30\u3002<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b<\/strong><strong>\u78ba\u8a3a\u8a55\u4f30\u65b9\u5f0f<\/strong><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li>\u81e8\u5e8a\u75c7\u72c0\u8a55\u4f30<\/li>\n<li>\u5c3f\u6db2\u6709\u6a5f\u9178\u6aa2\u67e5<\/li>\n<li><em>ETFA, ETFB, ETFDH<\/em> \u57fa\u56e0\u7a81\u8b8a\u5206\u6790\u3002<\/li>\n<li>\u6aa2\u6e2c\u76ae\u819a\u7e96\u7dad\u6bcd\u7d30\u80deETF\u548cETF:QO\u7684\u91af\u57fa\u8089\u9e7c\u5206\u6790(acylcarnitine profile)\u8207\u86cb\u767d\u8cea\u6e2c\u5b9a\u3002<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b<\/strong><strong>\u6cbb\u7642\u65b9\u5f0f<\/strong><\/span><\/p>\n<ul style=\"text-align: justify;\">\n<li>\u56b4\u91cd\u578b\u60a3\u8005\u9700\u8981\u4f5c\u98f2\u98df\u63a7\u5236\uff0c\u98df\u7528\u4f4e\u86cb\u767d\u8cea\u3001\u4f4e\u8102\u80aa\u3001\u9ad8\u78b3\u6c34\u5316\u5408\u7269\u7684\u98f2\u98df\u3002<\/li>\n<li>\u88dc\u5145\u6838\u9ec3\u7d20\u3001Coenzyme Q10 \u3001Glycine\u8207\u8089\u9e7c(Carnitine) \u6709\u52a9\u65bc\u8eab\u9ad4\u7522\u751f\u80fd\u91cf\u3002<\/li>\n<li>\u907f\u514d\u98e2\u9913\u8207\u58d3\u529b(\u5982\u767c\u71d2)\u3002<\/li>\n<li>\u665a\u767c\u578b\u60a3\u8005\u5728\u904b\u52d5\u524d\u8981\u6ce8\u610f\u591a\u651d\u53d6\u71b1\u91cf\uff0c\u907f\u514d\u6fc0\u70c8\u7684\u904b\u52d5\u3002\u7576\u767c\u75c5\u6642\uff0c\u61c9\u5373\u65e9\u5c31\u91ab\uff0c\u975c\u8108\u6ce8\u5c04\u8461\u8404\u7cd6\uff0c\u4ee5\u514d\u75c5\u60c5\u60e1\u5316\u3002<\/li>\n<\/ul>\n<h3><strong><span style=\"font-size: 14pt;\">\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b<\/span>\u7684\u7be9\u6aa2\u65b9\u6cd5<\/strong><\/h3>\n<ul>\n<li style=\"text-align: justify;\">\u7b2c\u4e00\u7dda\u6aa2\u9a57\n<ul style=\"list-style-type: square;\">\n<li>\u6aa2\u9a57\u65b9\u5f0f\uff1a\u751f\u5316\u6aa2\u9a57\uff0c\u4f7f\u7528\u542b\u7a69\u5b9a\u540c\u4f4d\u7d20\u6a19\u8a18\u7684\u5167\u90e8\u6a19\u6e96\u54c1\uff08Internal Standard\uff09\u6eb6\u5291\u8403\u53d6\u4e7e\u71e5\u8840\u9ede\u4e2d\u7684\u8102\u80aa\u9178\uff0c\u518d\u4ee5\u4e32\u806f\u8cea\u8b5c\u5100\uff08MS\/MS\uff09\u9032\u884c\u5206\u6790\u3002\uff08111.3-\u81f3\u4eca\uff09<\/li>\n<li>\u6aa2\u9a57\u8a66\u5291\uff1aNeoBase<sup>TM<\/sup>\u00a02 Non-derivatized MSMS kit\uff08PerkinElmer\uff09<\/li>\n<\/ul>\n<\/li>\n<li>\u7b2c\u4e8c\u7dda\u6aa2\u9a57\n<ul style=\"list-style-type: square;\">\n<li style=\"text-align: justify;\">\u6aa2\u9a57\u65b9\u5f0f\uff1a\u57fa\u56e0\u6aa2\u6e2c\uff0c\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff08Next Generation Sequencing\uff0cNGS\uff09\u3002\uff08108.10-\u81f3\u4eca\uff09<\/li>\n<li style=\"text-align: justify;\">\u6aa2\u9a57\u8a66\u5291\uff1aFatty Acids 7-Gene Lib Prep Kit\uff08Qiagen\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u4ec0\u9ebc\u662f\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b\uff1f \u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b\u662f\u8102\u80aa\u9178\u6c27\u5316\u904e\u7a0b\u7570\u5e38\u7684\u75be\u75c5\uff0c\u8d77\u56e0\u70ba\u4f4d\u65bc\u7c92\u817a\u9ad4\u57fa\u8cea\u5167Electron  &#8230; <a title=\"\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b (GA II)\" class=\"read-more\" href=\"https:\/\/www.cfoh.org.tw\/index.php\/item\/ga-ii\/\" aria-label=\"\u95b1\u8b80\u3008\u620a\u4e8c\u9178\u8840\u75c7\u7b2c\u4e8c\u578b (GA II)\u3009\u5168\u6587\">\u95b1\u8b80\u5168\u6587<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":781,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/P9uzrk-9r","_links":{"self":[{"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/pages\/585"}],"collection":[{"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/comments?post=585"}],"version-history":[{"count":4,"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/pages\/585\/revisions"}],"predecessor-version":[{"id":2636,"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/pages\/585\/revisions\/2636"}],"up":[{"embeddable":true,"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/pages\/781"}],"wp:attachment":[{"href":"https:\/\/www.cfoh.org.tw\/index.php\/wp-json\/wp\/v2\/media?parent=585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}